Vagal Nerve Stimulation for Intractable Epilepsy
History of Vagal Nerve Stimulation
1925 Berger: EEG from human scalp
1938 Baily & Bremer: fast wave induced in cats
1952 Zanachitti: desynchronization of EEG in cats block interictal spikes
1961 Magnes: synchronization (1-16 Hz) desynchronization (30Hz-)
1966 Chase: impoortance of parameters
1985 Zabara: abort convulsion in dogs
1990 Lockerd: chronic stim decreases epi attacks (monkey)
Perry & Dean (1990): 4 pts: complete control in 2 40% reduction in 1, no change in 1
Uthman (1990): 5 pts; 50% reduction in 3, 32% in 1, no change in 1
Japanese Clinical Trial 1992-
迷走神経刺激装置治験グループ
東北大学、東京女子医科大学、都立神経病院、近畿大学、鳥取大学、島根医科大学、鹿児島大学
